Aflatoxins, produced by Aspergillus spp., are toxic contaminants of stored grain. This study describes 50 dogs presented with foodborne aflatoxicosis.
Common clinical signs included lethargy (78%), vomiting (76%), anorexia (74%), icterus (66%), depression (66%), melena (60%), haematuria (36%) and diarrhea (36%). Common laboratory abnormalities included increased activities of aspartate aminotransferase (86%), alkaline phosphatase (84%) and alanine aminotransferase (79%), hypoantithrombinaemia (86%), prolonged prothrombin (PT, 82%) and activated partial thromboplastin times (aPTT, 80%), hyperbilirubinaemia (73%), hypocholesterolaemia (60%) hypoalbuminemia (47%) and thrombocytopenia (42%).
Non-survivors had longer PT and aPTT and lower antithrombin at presentation compared to survivors. Hyperbilirubinaemia (>56.6 μmol/L) and albumin concentration <32.5 g/L at presentation were risk factors for mortality. Common complications included disseminated intravascular coagulation (58%), hepatic encephalopathy (35%) and acute kidney injury (4%). The mortality rate was 68%, suggesting that dogs with aflatoxicosis have poor prognosis.
Source: Y. Bruchim et al., 2012. Accidental fatal aflatoxicosis due to contaminated commercial diet in 50 dogs. Res Vet Sci 93: 279-287. doi: 10.1016/j.rvsc.2011.07.024
Is the Proportions whole food nutrition program a healthier alternative to conventional diets?
The maker of raw and holistic diets seeks to help transform pets through its products, philosophy, education and research
This small family business prepares to introduce innovative, functional formulations beyond its signature cherry products
Processors should carefully develop, validate and implement an effective kill step to support production of pathogen-free petfoods
The new US food safety legislation will also affect regulation of petfood
What you need to keep your manufacturing line clean, safe and contaminant-free
--- Thank you for your patience ----
If you have any issues logging in or any other need feel free to contact us.