Canine atopic dermatitis (CAD) is an inflammatory skin
disorder characterized by pruritus and associated cutaneous changes. A dietary
intervention using polyunsaturated fatty acids (PUFA) has been shown to
alleviate symptoms in some dogs.
It is proposed that dietary PUFA are integrated into mast
cell membranes resulting in a reorganization of membrane microdomains. This may
then be accompanied by functional changes of membrane-associated proteins such
as the phospholipases D, enzymes having an important impact on mast cell
Schumann et al., 2014. Treating
canine atopic dermatitis with unsaturated fatty acids: the role of mast cells
and potential mechanisms of action. JAPAN
online, March 2014. doi: 10.1111/jpn.12181.
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