Advertisement

On June 20, 2012

Methyl nutrients inhibit growth of feline lymphoma

These results could be useful in developing dietary strategies for treating and preventing feline lymphoma.

Feline lymphoma is one of the most frequently diagnosed tumors in cats. Lipotropes are dietary methyl donors that may modulate DNA methylation status and the expression of genes involved in growth and apoptosis of feline lymphoma cells. The specific objective of the study was to determine if lipotropes affect the growth of feline lymphoma cells, which entailed examining a correlation between lymphoma cell proliferation and apoptosis.

F1B and FeLV-3281 cells were cultured and treated with 20 times the level of lipotropes contained in the basal culture medium. Cell growth and death and caspase 3 and tumor protein p53 activity were measured. Lipotropes were found to significantly reduce cell growth and increase cell death. Caspase 3 and p53 activity was seen in F1B cells after 72 hours, but the effect was minimal on FeLV-3281.

These results could be useful in the development of dietary strategies for treating and preventing feline lymphoma.

Source : L. Mabasa et al., 2012. Lipotropes (methyl nutrients) inhibit growth of feline lymphoma in vitro. Res Vet Sci 93: 259-263. doi: 10.1016/j.rvsc.2011.05.015

Comments powered by Disqus

Advertisement

Advertisement

Advertisement

Read the April issue of Petfood Industry!

April 2015

The April 2015 issue of Petfood Industry looks at different pet food markets around the world. Read about Sojos, a US company which aims to transform the lives of pets through raw pet food. As these specialized diets become increasingly popular in the dog and cat food markets, learn how such trends are carrying over into bird and small animal food. Plus, see how pet food companies in Russia are reacting and reconsidering production strategies in the wake of rising prices due to exchange rate fluctuations.

READ MORE in Petfood Industry magazine

Advertisement