Stratum Nutrition in collaboration with the Traditional & Biomedical Research Center within Daejeon University and Ju Yeong NS Co., Ltd., announce a new research study on NEM brand eggshell membrane has been published. The study further validates NEM’s mechanism of action and reveals exciting insights on NEM’s ability to support joint health.
Researchers evaluated three doses of NEM (including the human equivalent dose of 52 mg/kg) in a rat model of osteoarthritis. As in prior research, NEM again demonstrated powerful anti-inflammatory effects, in this case on the inflammation biomarkers Interleukin 1-beta (IL-1b) and C-Reactive Protein (CRP). And, for the first time, chondroprotective effects were revealed from NEM treatment. NEM was found to reduce circulating cartilage degrading enzymes known as Matrix Metalloproteinases (MMPs) and was shown to reduce serum levels of the cartilage degradation biomarker CTX-II. Importantly, the demonstrated chondroprotective effects were validated through histology, wherein a blinded pathologist evaluated cartilage thickness and joint space width both microscopically and via micro CT scan. The results of this study were published in the August issue of the Journal of Nutrition and Health.