The objective of this research was to determine the expression of tight junction and adherens junction proteins in duodenal mucosa samples of dogs with inflammatory bowel disease (IBD).
Duodenal mucosa samples were endoscopically obtained from 12 dogs with IBD and six healthy control Beagles, focusing on claudin-1, -2, -3, -4, -5, -7 and -8; E-cadherin; and Î²-catenin. The expression of each claudin and Î²-catenin was not significantly different between control dogs and dogs with IBD. However, expression of E-cadherin was significantly lower in duodenal mucosa samples of dogs with IBD than it was in samples obtained from healthy control dogs.
Results of this study indicated expression of claudin-1, -2, -3, -4, -5, -7 and -8 and Î²-catenin was not significantly different between duodenal mucosa samples obtained from control dogs and those obtained from dogs with IBD. However, E-cadherin expression was significantly lower in the villus epithelium in duodenal mucosa samples obtained from dogs with IBD, which suggested that decreased expression of that protein has a role in the pathogenesis of IBD in dogs.
Source: Hiroshi Ohta PhD et al., 2014. Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease. AJVR online, August 2014. doi: 10.2460/ajvr.75.8.746.
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