Treating canine atopic dermatitis with unsaturated fatty acids

Canine atopic dermatitis (CAD) is an inflammatory skin disorder characterized by pruritus and associated cutaneous changes. A dietary intervention using polyunsaturated fatty acids (PUFA) has been shown to alleviate symptoms in some dogs.

Canine atopic dermatitis (CAD) is an inflammatory skin disorder characterized by pruritus and associated cutaneous changes. A dietary intervention using polyunsaturated fatty acids (PUFA) has been shown to alleviate symptoms in some dogs.

It is proposed that dietary PUFA are integrated into mast cell membranes resulting in a reorganization of membrane microdomains. This may then be accompanied by functional changes of membrane-associated proteins such as the phospholipases D, enzymes having an important impact on mast cell exocytosis processes.

Source:  J. Schumann et al., 2014. Treating canine atopic dermatitis with unsaturated fatty acids: the role of mast cells and potential mechanisms of action. JAPAN online, March 2014. doi: 10.1111/jpn.12181.

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