MycoDog announced results from a study evaluating its Clarity supplement, a blend of medicinal mushrooms and adaptogens, in senior dogs showing signs of cognitive decline. The research was conducted by Veterinary Health Research Centers with Dr. Joel Ehrenzweig, DVM, MRCVS, as study director and Carter Easler as principal investigator.
Thirty senior dogs participated in the 12-week protocol, which combined at-home caregiver assessments and wearable tracking with in-clinic evaluations and blood analysis. Cognitive function was measured using the DISHAA framework, with biomarkers CRP (inflammation) and BDNF (neuroprotection) tracked in clinic.
The study found 81% of dogs improved or stabilized cognitive scores, with a 39% average reduction in cognitive dysfunction scores. Dogs showed improvements in orientation, sleep, engagement and house training. Smart-collar data confirmed calmer nights and better sleep quality. Biomarkers indicated reduced inflammation and increased BDNF. No supplement-related adverse events were reported.
"Clarity may offer valuable, non-pharmaceutical support for cognitive health, especially in early to moderate cases of canine cognitive decline," said Dr. Ehrenzweig. "These results represent a meaningful step forward in how we understand natural compounds for aging pets. The study's mixed design, combining real-world tracking with clinical biomarkers, adds strength to its conclusions."
Mushrooms have been used in traditional medicine for centuries, and now modern research is proving why, noted Easler. "Fungi share nearly 30% of their DNA with animals, which helps explain their profound biological compatibility," he noted. "Ingredients like Lion's Mane and Bacopa Monnieri have been shown to support neuron regeneration and telomere repair, which may be key to preserving cognitive function as dogs age."
MycoDog's Clarity contains Lion's Mane, Reishi and Cordyceps mushrooms along with adaptogens Ashwagandha and Bacopa Monnieri. The mushrooms are cultivated on natural substrates and extracted using dual and spagyric methods. The company was founded by Angela Ardolino, a clinician and researcher who has worked in holistic animal care for more than 20 years.
"For more than a decade, I've been studying and using these fungi and adaptogens in clinical practice with rescue dogs," said Ardolino. "Clarity was formulated from that research and real-world case experience. We're now seeing what I've witnessed for years -- dogs reversing signs of cognitive decline and reconnecting with their families. These ingredients aren't just extending life, they're improving its quality."
The next phase of research will expand the virtual cohort to include more senior dogs in real-world settings. Pet parents interested in participating can visit SeniorDogStudy.com to learn more.
"Just like us, senior dogs need extra help to stay sharp and balanced, and nature provides it," added Ardolino. "This is what next-generation wellness looks like - helping our dogs age with the same care, dignity, and vitality we want for ourselves."
