The aim of this study was to investigate anti-arthritis activity using natural eggshell membrane (NEM).

NEM was administered at 52 mg/kg, 200 mg/kg and 400 mg/kg to rats, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines (IL-1β and IL-6) were measured, as well as PGE2, MMP-2, MMP-9, TIMP-1, LTB4 and hs-CRP. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Production of NO, IL-1β, IL-6, PGE2, MMP-2, MMP-9, TIMP-1, LTB4 and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane and transformation of fibrous tissue.

The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease some arthritis symptoms.

Source: Boo Yong Sim et al., 2015. Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats. J Nutr Health online, August 2015. doi: 10.4163/jnh.2015.48.4.310